產品屬性：
產品名稱 | trans-Resveratrol-d4 |
規(guī)格 | 100 μg、250 μg、500 μg、1 mg |
貨號 | EY-01Y20603 |
Cas No.: 1089051-56-8
別名: N/A
化學名: N/A
分子式: C14H8D4O3
分子量: 232.3
溶解度: DMF: >100 mg/ml,DMSO: >50mg/ml,Ethanol: >50mg/ml,PBS (pH 7.2): <100 μg/ml
儲存條件: Store at -20°C
General tips:For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition:Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
trans-Resveratrol-d4 is intended for use as an internal standard for the quantification of trans-resveratrol by GC- or LC-MS. trans-Resveratrol is a polyphenolic phytoalexin found in a variety of plants, including grapes, that has anti-inflammatory, antioxidant, and anticancer activities.1,2 It inhibits the cyclooxygenase and hydroperoxidase activities of COX-1 (EC50s = 15 and 3.7 μM, respectively), but not COX-2 (EC50s = >100 μM and 85 μM, respectively).1 trans-Resveratrol (3 and 8 mg/kg) inhibits carrageenan-induced paw edema in mice. It inhibits free radical formation in HL-60 human promyelocytic leukemia cells induced by phorbol 12-myristate 13-acetate . trans-Resveratrol (1-25 μmol) reduces both the incidence and number of tumors in a two-stage mouse model of skin cancer induced by TPA and 7,12-dimethyl-benz[a]anthracene (DMBA). trans-Resveratrol (200 μM) also activates sirtuin 1 (SIRT1) by 8-fold in vitro and inhibits a variety of targets including ERK1, JNK1, Src, PKCα, aromatase/CYP19, and DNA polymerases α and δ (IC50s = 37, 50, 20, <10, 25, 3.3, and 5 μM, respectively) in vitro and/or ex vivo.3,2 It prolongs lifespan in model organisms including C. elegans, D. melanogaster, and mice.2 1.Jang, M., Cai, L., Udeani, G.O., et al.Cancer chemopreventive activity of resveratrol, a natural product derived from grapesScience275(5297)218-220(1997)
2.Pirola, L., and Fr?jd?, S.Resveratrol: One molecule, many targetsIUMBM Life60(5)323-332(2008)
3.Borra, M.T., Smith, B.C., and Denu, J.M.Mechanism of human SIRT1 activation by resveratrolJ. Biol. Chem.280(17)17187-17195(2005)
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