產(chǎn)品屬性：
產(chǎn)品名稱 | JMV 449 acetate |
規(guī)格 | 5 mg、10 mg |
貨號 | EY-01Y12231 |
Cas No.: N/A
別名: N/A
化學(xué)名: N/A
分子式: C40H70N8O9
分子量: 807.03
溶解度: H2O: 100 mg/mL (123.91 mM)
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產(chǎn)品描述：
JMV 449 acetate is a potent neurotensin receptor agonist. JMV 449 acetate shows an IC50 of 0.15 nM for inhibition of 125I-neurotensin binding to neonatal mouse brain and an EC50 of 1.9 nM in contracting the guinea-pig ileum. JMV 449 acetate has highly potent and long-lasting hypothermic and analgesic effects in the mouse[1][2].JMV 449 (120 pmol/mouse; i.c.v) shows analgesic effect[2].Animal Model:Male Swiss albino mice[1][1]. Lugrin D, et al. Reduced peptide bond pseudopeptide analogues of neurotensin: binding and biological activities, and in vitro metabolic stability. Eur J Pharmacol. 1991;205(2):191-198.
[2]. Dubuc I, et al. JMV 449: a pseudopeptide analogue of neurotensin-(8-13) with highly potent and long-lasting hypothermic and analgesic effects in the mouse. Eur J Pharmacol. 1992;219(2):327-329.
特別提醒公司產(chǎn)品僅供科研使用
